Revacept (PR-15, GPVI-Fc)

Platelet adhesion to arterial vascular lesions and plaques plays a key role in the complications of atherosclerosis leading to acute coronary syndromes and myocardial infarctions as well as ischemic cerebral stroke.

Revacept is a human Fc fusion protein, which prevents the local activation of platelets at sites of vascular injury, acting like a “vascular coating”. Efficacy studies showed that revacept resulted in significantly reduced thrombus formation at these sites. However, systemic hemostasis is not affected.

In a first in man study, all doses were well tolerated, no drug-related adverse events occurred, bleeding time was not prolonged. No bleeding complications nor platelet depletion (thrombopenia) were observed.