anti-GPVI antibodies

Platelet adhesion to arterial vascular lesions and plaques can also be inhibited by using antibodies which specifically block glycoprotein VI -dependent signal pathways.

Such monoclonal antibodies were designed in a cooperation with the group of Meinrad Gawaz (now: Medical Clinic III of the University of Tübingen) and Dr. Kremmer at Helmholtz Centre Munich, Germany. Efficacy studies showed that also these antibodies resulted in significantly reduced thrombus formation at these sites, but systemic hemostasis was not affected.

Also these antibodies and fully human variants have already been tested in preclinical studies for efficacy and safety. The group of Prof. Siess at the institute for cardiovascular research at Munich investigated their efficacy by using human carotid surgery-derived plaques which were superfused with human blood.

The pros and cons of using such anti-glycoprotein VI antibodies versus glycoprotein VI fusion proteins are discussed in the recent editorial of Kleiman und Kolandaivelu „Expanding the Roster : Developing New Inhibitors of Intravascular Thrombosis“ in the Journal of the American College of Cardiology 2015; 65 (22): 2416 – 2419.