Anti-TSH receptor-mediated thyroid disease (Graves´ disease)
In Graves´ disease, auto-antibodies are directed against native TSH receptors in the thyroid gland, which they activate like the naturally occurring hormone TSH. This mechanism leads to a chronic excess stimulation of these important regulatory receptors and consecutive hyperthyroidism.
Novel cyclic peptides effectively treat the auto-antibody-mediated propagation of hyperthyroidism. They reduce stimulatory antibodies by immune interference. In disease models, the cyclic peptides successfully improved goiters (thyroid enlargements) and hyperthyroidism and also cured eye symptoms (“auto-immune orbitopathy”) which frequently occur in this condition and are especially hard to treat.